Abbott Hepatitis C Combo Impressive in Small Study
> Reuters (04.02.12)::Bill Berkrot
> A combination of oral hepatitis C drugs being developed by
> Abbott Laboratories realized cure rates exceeding 90 percent in
> treatment-na?ve patients, according to a small, mid-stage study. The
> results, released Wednesday, will be presented later this month in
> Barcelona at a meeting of the European Association for the Study of the
> For 12 weeks, patients in the Phase II trial, known as
> ?Co-Pilot,? received Abbott?s protease inhibitor ABT-450, boosted by the
> antiviral drug ritonavir with its polymerase inhibitor ABT-333, and
> ribavirin, which is used in all current hepatitis C regimens. Patients?
> blood virus levels were checked 24 weeks later for a sustained virologic
> response. Those achieving SVR were considered cured.
> Eighteen of the 19 patients (95 percent) given 250 milligram
> doses of ABT-450 in their combination achieved SVR. Thirteen of 14 patients
> (93 percent) given 150 mg doses of ABT-450 achieved SVR.
> ?This demonstrates unprecedented cure rates for the most common
> form of hepatitis C infection,? said Scott Brun, Abbott?s divisional vice
> president for infectious disease development. Although confirming the
> effectiveness and safety of the drugs requires much larger trials, Abbot
> maintains it is on track to embark on Phase III testing early next year.
> In a third portion of the study concentrating on patients
> unresponsive to the standard regimen of interferon and ribavirin, 8 of 17
> (47 percent) achieved SVR. Abbott is hopeful an NS5A inhibitor it is
> testing in several all-oral combinations will boost SVR rates of previous
> Dan Bigg, Director email@example.com
> Chicago Recovery Alliance www.anypositivechange.org
> 3110 W Taylor St voice 1-312-953-3797
> Chicago IL 60612 fax 1-773-489-7448
Event: Law Enforcement Safety & Drug Policy Summit
WHEN: June 12th, 2012
WHAT TIME IS THE EVENT: Registration starts at 8 am, and the event begins at 9 am and will go through Noon. A lunch will be served to registered guests after the summit.
WHERE: North Carolina Legislative Auditorium, 16 Jones Street, Raleigh, NC
WHO SHOULD ATTEND: Law Enforcement, Legislators, Legislative Support Staff, Public Health Officials, Lobbyists, Harm Reductionists, Drug Policy Reformers, Policy Reformers, People Who Work With Incarcerated Populations and the Substance Abuse Community
WHAT WILL BE COVERED: Law Enforcement Needlestick Reduction, Law Enforcement Safety around Drug Overdoses, Reducing Recidivism While Maintaining Public Order and Drug Policy Reform
WHO WILL BE PRESENTING: Law Enforcement Safety Experts, Law Enforcement, Drug Policy Experts and Republican & Democratic Legislators, and Conservative, Liberal & Moderate Policy Institutes
EVENT CONTACT: Robert Childs, MPH (336) 543-8050, firstname.lastname@example.org
SIGN-UP PAGE: http://tinyurl.com/NCdrugpolicy
Just an FYI: The Southern Harm Reduction Conference will take place in mid-September 2012 in Atlanta this year. More details soon!